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目的观察贝那普利联合美托洛尔治疗老年原发性高血压合并心力衰竭的临床效果。方法选取2014年7月-2016年4月医院收治的老年原发性高血压合并心力衰竭患者144例,采用随机数字表法分为观察组和对照组各72例;对照组给予贝那普利治疗,观察组在对照组治疗的基础上给予美托洛尔治疗,比较2组患者治疗前后的血压、超声心动图改善情况及临床疗效。结果治疗前2组患者舒张压(DBP)、收缩压(SBP)、左室舒张末径(LVEDD)、左心室收缩末期内径(LVESD)及左心射血分数(LVEF)对比无显著差异(P>0.05);治疗后2组SBP、DBP、LVEDD及LVESD均明显降低,LVEF明显升高,且观察组SBP、DBP、LVEDD及LVESD低于对照组,LVEF高于对照组,差异均有统计学意义(P<0.05)。观察组总有效率为93.06%高于对照组的77.78%,差异有统计学意义(P<0.05)。结论贝那普利联合美托洛尔治疗老年原发性高血压合并心力衰竭能显著降低血压,改善患者心功能,提高临床治疗效果。
Objective To observe the clinical effect of benazepril combined with metoprolol in the treatment of senile essential hypertension complicated with heart failure. Methods 144 patients with senile essential hypertension complicated with heart failure admitted to our hospital from July 2014 to April 2016 were randomly divided into observation group (n = 72) and control group (n = 72). The control group was given benazepril The treatment group and the observation group were treated with metoprolol on the basis of the control group. The blood pressure and echocardiography were compared between two groups before and after treatment to improve the situation and clinical efficacy. Results There were no significant differences in DBP, SBP, LVEDD, LVESD and LVEF between the two groups before treatment (P > 0.05). After treatment, SBP, DBP, LVEDD and LVESD were significantly decreased and LVEF were significantly increased in the two groups, SBP, DBP, LVEDD and LVESD in the observation group were lower than those in the control group, and the differences were statistically significant Significance (P <0.05). The total effective rate in the observation group was 93.06% higher than that in the control group (77.78%), the difference was statistically significant (P <0.05). Conclusion The combination of benazepril and metoprolol in the treatment of elderly patients with essential hypertension complicated with heart failure can significantly lower blood pressure, improve cardiac function and improve clinical effect.