1976年Ross与Glomset创立了内皮细胞损伤学说,打开了血管病原学研究的新领域。Ross在最初的理论中提出长期高血压及血流冲击等切应力促使内皮损伤,引起血小板聚集及释放血管活性物质,造成血栓形成与血管收缩。1993年又阐述,内皮细胞功能障碍学说。在动脉硬化的初始病灶上,单核 In 1976 Ross and Glomset founded the theory of endothelial cell injury, opening up new areas of vasculogenic research. In the original theory, Ross proposed that long-term hypotension and shear stress such as blood flow impact promote endothelial injury, cause platelet aggregation and release of vasoactive substances, resulting in thrombosis and vasoconstriction. 1993 also elaborated on the theory of endothelial dysfunction. In the initial lesions of atherosclerosis, mononuclear