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一、对母鼠的毒性和对子代幼鼠的影响作者首次报导将大鼠慢性暴露于铅的一系列研究结果。断乳的雌鼠给子不含铅的半纯化的食物和含0、0.5、5、25、50和250PPm铅(以醋酸铅计)的饮用水。大鼠暴露于醋酸铅6～7周后进行交配,在整个怀孕期、哺乳期继续暴露于铅。所有不同的实验组对食物和饮用水的摄入量,在统计学上没有显著差异。50和250PPm组的雌鼠,在暴露开始后的第1～3
I. Toxicity to Dams and Impact on Offspring The authors first reported a series of studies that chronically exposed rats to lead. Wean-fed females gave non-lean, semi-purified food and drinking water containing 0, 0.5, 5, 25, 50 and 250 ppm lead (calculated as lead acetate) Rats were exposed to lead acetate for 6 to 7 weeks after mating, throughout the pregnancy, breast-feeding continued exposure to lead. There was no statistically significant difference in the intake of food and drinking water among all the different experimental groups. Females in the 50 and 250 PPm groups were 1 to 3 after the start of the exposure