本研究包括对大、小鼠的急性毒性及对家兔的眼刺激试验 ,Ames试验、小鼠骨髓细胞微核试验及小鼠睾丸精母细胞染色体畸变试验。急性经口、经皮试验结果表明“84 0”生物杀虫剂属低毒农药。眼刺激试验结果表明该生物杀虫剂属轻度刺激性农药。Ames试验、小鼠骨髓细胞微核试验及小鼠睾丸精母细胞染色体畸变试验三项试验结果均为阴性 ,表明该生物杀虫剂在试验剂量范围内没有明显的致突变作用。 This study included acute toxicity to large mice and mice, eye irritation test in rabbits, Ames test, micronucleus test in mouse bone marrow cells and chromosome aberrations in mouse testicular spermatocytes. Acute oral and transdermal test results show that the “84 0” biopesticide is a low toxicity pesticide. Eye irritation test results show that the biopesticide is a mild irritating pesticide. Ames test, mouse bone marrow micronucleus test and mouse testicular spermatocyte chromosome aberration test results of the three tests were negative, indicating that the bio-pesticides in the experimental dose range no significant mutagenic effect.