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目的:研究国产卡铂(CBP)的临床药物动力学与药效学,方法:12例肿瘤病人iv gtt CBP 400mg,用反相HPLC法测定血清CBP浓度,并按残数法拟合药物动力学模型和参数.结果:12例肿瘤病人iv gtt CBP结束时的平均血药浓度(?).为55.10±13.00)mg/L,消除半衰期(T._(2?))为(143.09±49.36)min,清除率(CL)为(45.17±16.68)ml min.有效组和无效组的(?)分别为(61.03±9.28)和(52.14±12.77)mg/L,T_(?)分别为(191.27±26.92)和(119.00±35.31)min(P<0.01),CL分别为(31.42±6.79)和(52.04±15.97)ml/min(P<0.05).在2~10h内.有效组血清CBP浓度高于无效组(P<0.05).结论:肿瘤病人iv gtt CBP的血药浓度存在明显个体差异,且疗效与血药浓度和清除快慢有关.
Objective: To study the clinical pharmacokinetics and pharmacodynamics of domestic carboplatin (CBP). Methods: Twelve patients with tumor were treated with iv gtt CBP 400 mg. The concentration of serum CBP was determined by reversed-phase HPLC. The pharmacokinetics Model and parameters.Results: The average plasma concentration of iv gtt CBP at 12 months was 55.10 ± 13.00 mg / L, and the elimination half life was (143.09 ± 49.36) min, and the clearance rate (CL) was (45.17 ± 16.68) ml min. The effective rate and effective rate were (61.03 ± 9.28) and (52.14 ± 12.77) mg / (31.42 ± 6.79) and (52.04 ± 15.97) ml / min, respectively (P <0.05) .In the range of 2 ~ 10h, the effective concentration of serum CBP (P <0.05) .Conclusion: The plasma concentration of iv gtt CBP in tumor patients has obvious individual differences, and the curative effect is related to the concentration of blood and the clearance rate.