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异搏停、硝苯吡啶和硫氮革酮等钙拮抗剂又称慢通道阻滞剂,其中异搏停已广泛应用于各种室上性心动过速、心绞痛、高血压和特发性肥厚性主动脉瓣下狭窄。异搏停和心得安等β-受体阻滞剂同样具有负性变力(inotropic)、变时(chronotropic)和变(传)导(dromotropic)效应,以往一向认为两者不能联合应用。用β-受体阻滞剂的患者,有必要用异搏停时,必须停用β-受体阻滞剂48小时。然而,两者抑制心脏的机理不同,β-受体阻滞剂的负性变力、变时和变导效应是通过对细胞膜β-肾上腺能受体的竞争性抑制来实现的,而钙拮抗剂的这些效应是通过解除兴奋-收缩的耦联起作用的。
Verapamil, nifedipine and sulfonylurea and other calcium antagonists, also known as slow channel blockers, of which verapamil has been widely used in a variety of supraventricular tachycardia, angina, hypertension and idiopathic hypertrophy Aortic valve stenosis. Beta-blockers such as verapamil and propranolol also have inotropic, chronotropic, and dromotropic effects and have historically not been considered as useful in combination. In patients with beta-blockers, it is necessary to stop using verapamil and beta-blockers must be discontinued for 48 hours. However, the mechanism of the two inhibition of the heart is different, β-blockers negative variable force, variable time and the induction effect through the inhibition of the cell membrane β-adrenergic receptor to achieve, and calcium antagonist These effects of the agent work by releasing the excitement-contraction coupling.