米托蒽醌(mitoxantrone,MA)是一种蒽醌抗肿瘤药,其结构与阿霉素相似,但其母体分子C~9上无氨基葡萄糖部分(图1)。 图1.米托蒽醌结构式 药理学和药物动力学 MA的机理未明。可认作非特异性细胞周期药,因它可杀灭任何细胞周期的癌细胞,增殖与非增殖细胞均受抑制;但对分裂期细胞比休止期细胞更敏感。对细胞周期“S”后期最为敏感。 Mitoxantrone (MA) is an anthraquinone antineoplastic agent that has a similar structure to doxorubicin but does not contain any glucosamine moiety on its parent molecule C-9 (Figure 1). Figure 1. Mitoxantrone structural pharmacology and pharmacokinetics MA mechanism is unknown. Can be considered as non-specific cell cycle drugs, because it can kill any cell cycle of cancer cells, proliferation and non-proliferating cells are inhibited; but dividing cells are more sensitive than resting cells. Most sensitive to the late “S” cell cycle.