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Ｅｂｓｅｌｅｎ为一脂溶性有机硒化合物,可通过抑制脂质过氧化对缺血引起的脑损伤发挥保护作用。作者用ｅｂｓｅｌｅｎ对完全性ＭＣＡ闭塞病人进行了随机、双盲、安慰剂对照研究。采用ＮＩＨ影像学标准,测定随访ＣＴ所显示的最大梗死体积,病人的结局确定为主要终点。治疗?..
Ebselen is a fat-soluble organic selenium compound that protects against ischemia-induced brain injury by inhibiting lipid peroxidation. The authors used ebselen in a randomized, double-blind, placebo-controlled study of patients with complete MCA occlusion. NIH imaging criteria were used to determine the maximum infarct volume shown at follow-up CT and the patient’s outcome was defined as the primary endpoint. treatment?..