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目的：在观察颞下颌关节骨关节病（ＴＭＪＯＡ）大体病变及组织病理学改变的基础上，研究ＯＡ在超微结构水平上的病理变化。方法：１％胶原酶诱导建立ＴＭＪＯＡ实验动物（山羊）模型，于各间期处死，取病变标本做大体、组织化学染色及超微结构观察研究。结果：实验１月组关节标本开始出现骨关节病改变，随实验间期延长而加重，至实验３月组达顶峰。结论：ＴＭＪＯＡ的病变是进行性发展的，机体的自我修复过程缺乏正常的产物，不能阻遏ＯＡ的病变发展
OBJECTIVE: To study the pathological changes of OA at the ultrastructure level on the basis of observing the gross pathological changes and temporomandibular changes of temporomandibular joint osteoarthrosis (TMJOA). Methods: The TMJOA experimental animal (goat) model was induced by 1% collagenase and sacrificed at various intervals. The lesions were examined by gross, histochemical staining and ultrastructure. Results: In January, the joint specimens began to show the change of osteoarthropathy, which aggravated with the prolongation of the experimental period, reaching the peak in the experimental group in March. Conclusion: TMJOA lesions develop progressively, and the body's self-repair process lacks normal products and can not block the development of OA lesions