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本研究应用19种单克隆抗体检测5例人类慢性B淋巴细胞性白血病(B—CLL)细胞的表现型,并据此进行免疫分型及细胞分化阶段的分析。根据表现型5例中有4例诊断为B—CLL,1例为幼淋巴细胞白血病(B—PLL),根据不同的轻链表达又分为κ型和λ型。4例B—CLL中有3例细胞处于中间分化阶段,1例处于中间与成熟分化阶段之间。1例B—PLL则处于成熟分化阶段。
In this study, 19 kinds of monoclonal antibodies were used to detect the phenotypes of 5 human chronic lymphocytic leukemia (B-CLL) cells, and the immunophenotyping and cell differentiation stages were analyzed. According to phenotype, 4 cases were diagnosed as B-CLL in 5 cases, and 1 case was B-PLL. According to different expression of light chain, they were divided into κ type and λ type. Three of the four B-CLL cells were in the intermediate stage of differentiation, with one in the intermediate and mature stage of differentiation. One case of B-PLL is in its mature stage of differentiation.