以5-磺基水杨醛为母体,经氯甲基化和硒化反应引入催化基团—SeH,此化合物经空气氧化、Schiff碱反应以及锰螯合反应,最终得到一种新型的水杨醛Schiff碱类谷胱甘肽过氧化物酶(GPX)模拟物.测定了该模拟物的红外光谱、核磁共振谱、质谱和抗氧化能力.此模拟物同时兼具超氧化物歧化酶(SOD)和过氧化氢酶(CAT)活性,水溶性好,保护线粒体免遭氧化损伤能力强,具有作为药物前体的潜力. 5-sulfosalicylaldehyde as the precursor, chloromethylation and selenization reaction catalyzed group-SeH introduction, the compound by air oxidation, Schiff base reaction and manganese chelation reaction, and ultimately get a new type of salicylide Aldehyde Schiff base glutathione peroxidase (GPX) mimics.The infrared spectrum, nuclear magnetic resonance spectrum, mass spectrometry and antioxidant capacity of the mimics were measured.The results show that the mimics both superoxide dismutase (SOD ) And catalase (CAT) activity, good water solubility, mitochondrial protection from oxidative damage, has the potential as a pro-drug.