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作者选择118例在门诊治疗的癫癎患者,其中男性81例,女性37例,平均年龄39.3岁(14—73岁)。全部合并使用抗癫癎药物(主要为苯妥英钠200—500毫克/日,苯巴比妥60～80毫克/日,扑癎酮250～1000毫克/日)。通过门诊检查、询问家属、追查以往病史以及对部份患者进行心理测验,收集下列资料:癫癎发作类型和频度;抗癫癎药物的种类、剂量与给药时间;是否存在精神运动性阻滞、智能减退、精神病或明显的人格障碍;是否有眼球震颤、呐吃或共济失调。在估价其精神状态时,不管其严重程度,只记录“有”或“无”。有精神异常或性格障碍者共有20例(精神分裂症样精神病4例,分裂性或妄想性人格3例,严重抑郁6例,行为障碍3例,癔病性格3例,强迫性和依赖人格1例)。用气相层析方法测定血清中苯妥英钠和苯巴比妥的浓
The authors selected 118 patients with epilepsy treated in the outpatient setting, including 81 males and 37 females, with an average age of 39.3 years (14-73 years). All combined use of anti-epileptic drugs (mainly phenytoin 200-500 mg / day, phenobarbital 60 to 80 mg / day, phentolamine 250 to 1000 mg / day). Through outpatient examination, interrogation of family members, tracing past medical history and psychological tests on some patients, the following data were collected: type and frequency of epilepsy seizures; type of antiepileptic drugs, dosage and administration time; presence of psychomotor resistance Lag, intellectual decline, mental illness or obvious personality disorder; whether there is nystagmus, na or ataxia. In valuing their mental state, only “yes” or “no” is recorded, regardless of their severity. There are 20 cases of mental disorders or disability (schizophrenia-like psychosis in 4 cases, 3 cases of disorganized or delusional personality, severe depression in 6 cases, behavioral disorders in 3 cases, 3 cases of hysteria, obsessive-compulsive and dependent personality in 1 case ). The concentrations of phenytoin and phenobarbital in serum were determined by gas chromatography