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目的观察生长抑素联合加贝酯治疗急性胰腺炎的临床效果。方法急性胰腺炎患者30例随机均分为两组,分别采用生长抑素和加贝酯联合治疗(A组)和单一生长抑素治疗(B组)。比较两组疗效和并发症发生情况。结果A组治疗有效率高于B组(93.3%vs.60.0%)(P<0.05)。A组腹痛缓解、白细胞和血淀粉酶恢复时间以及住院时间均短于B组(P<0.05或P<0.01)。A组并发感染1例;B组并发感染3例,器官衰竭2例,假性囊肿2例。A组并发症发生率低于B组(6.7%vs.46.7%)(P<0.05)。结论在抗感染、止痛和纠正水电解质紊乱等基础上,联合应用生长抑素和加贝酯治疗急性胰腺炎的临床效果优于单用生长抑素。
Objective To observe the clinical effect of somatostatin combined with gabexate in the treatment of acute pancreatitis. Methods Thirty patients with acute pancreatitis were randomly divided into two groups: the combination of somatostatin and gabexate (group A) and the single somatostatin (group B). The curative effect and complications of the two groups were compared. Results The effective rate of treatment in group A was higher than that in group B (93.3% vs.60.0%) (P <0.05). A group of abdominal pain relief, leukocyte and serum amylase recovery time and hospitalization were shorter than the B group (P <0.05 or P <0.01). A group complicated by infection in 1 case; B group complicated by infection in 3 cases, organ failure in 2 cases, 2 cases of pseudocyst. The incidence of complications in group A was lower than that in group B (6.7% vs.46.7%) (P <0.05). Conclusion The combination of somatostatin and gabexate in the treatment of acute pancreatitis has better clinical effect than that of somatostatin alone on the basis of anti-infective, analgesic and water-electrolyte disturbance.