在北越南部用来治疗抗氯喹恶性疟的主要药物是奎宁,但单用奎宁的复燃率为30～93%;在美军中每天用2g奎宁连续19天,其疗效与给药途径有关,静滴根治率为86%,而口服仅33%。从1966年起,以硫酸奎宁(650mg每8小时1次连续14天)伍用乙胺嘧啶(25mg每天3次,连续3天)作为标准治疗方案。作者等将85例经体外48小时改良法测定为抗氯喹的恶性疟病人分为3组。第一组 The main drug used to treat chloroquine-resistant falciparum malaria in northern Vietnam was quinine, but the rate of reactivation with quinine alone was 30-93%; in the U.S. Army, 2g quinine was used for 19 consecutive days, its efficacy and route of administration Related, intravenous cure rate was 86%, while only 33% orally. Starting from 1966, quinidine sulfate (650 mg once every 8 hours for 14 consecutive days) was given pyrimethamine (25 mg three times a day for 3 consecutive days) as a standard treatment regimen. The authors enrolled 85 patients who were challenged with chloroquine-resistant falciparum malaria by the 48-hour in vitro modification method and divided them into three groups. First group