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韦氏大风子Hydnocarpus wightiana主要生长于印度和马来亚地区,其种子富含大风子油。大风子油最早用于治疗麻风病和抑制瘤子的生长,现已逐渐为砜类药物所取代。随着,黄酮木脂素从韦氏大风子中的分离,此药的许多生物活性已有所报道。作者主要研究具有治疗作用的三种黄酮木脂素,即韦氏大风子亭(hydnwightin,1),次大风子素(hydnocarpin,2),新次大风子素(neo-hydnocarpin,3)的抗癌、降血脂和抗炎作用。
Webster’s windy Hydnocarpus wightiana is mainly grown in India and Malaya, and its seeds are rich in windy oil. It was first used to treat leprosy and inhibit the growth of tumors, and it has been gradually replaced by sulfone drugs. With the separation of flavonolignans from Welsh winds, many biological activities of this drug have been reported. The authors studied the three flavonoids with therapeutic effects, namely the resistance of hydnwightin (1), hydnocarpin (2), and neo-hydnocarpin (3). Cancer, hypolipidemic and anti-inflammatory effects.