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本研究首次在体外观察了抗坏血酸对胶原酶活性的抑制作用。结果表明:抗坏血酸浓度达56.7mmol/L有明显抑制胶原酶活性作用;浓度至85mmol/L在本反应体系中完全抑制胶原酶活性,加热破坏抗坏血酸后则失去抑制作用。这将进一步理解抗坏血酸在治疗角膜碱烧伤及角膜溃疡中的作用。
This study for the first time observed in vitro ascorbic acid on the inhibition of collagenase activity. The results showed that ascorbic acid concentration of 56.7mmol / L could significantly inhibit the activity of collagenase. The concentration of 85mmol / L could completely inhibit the activity of collagenase in this reaction system, and the loss of inhibition after heating and destroying ascorbic acid. This will further understand the role of ascorbic acid in the treatment of corneal alkali burns and corneal ulcers.