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1,3—丁二烯(CHB_2CHCHCH_2,BD)是丁烯类塑料、纤维、橡胶的基础原料,主要来源于石油裂解的C_4馏份。随着石化工业的迅速发展,1,3—BD产量和作业人数增长很快。在接触本品作业者的健康调查中,除常见的神衰综合征和呼吸道刺激症状外,我国还发现多例周围神经病变,这在国外文献中未见报导。为此,我们进行了1·3—BD的亚慢性毒性试验,并从生理、生化和形态结构等方面着重探讨了BD的神经毒性,尤其是对周围神经系统的毒作用。结果报导如下。
1,3-butadiene (CHB_2CHCHCH_2, BD) is the basic raw material for butene plastics, fibers and rubbers, mainly derived from the C_4 fraction of petroleum cracking. With the rapid development of the petrochemical industry, 1,3-BD production and operating personnel increased rapidly. In contact with the health survey of workers, in addition to the common symptoms of Shen Shen syndrome and respiratory irritation, many cases of peripheral neuropathy have also been found in our country, which has not been reported in foreign literature. To this end, we conducted a sub-chronic toxicity test of 1.3-BD and explored the neurotoxicity of BD, especially on the peripheral nervous system, from the aspects of physiology, biochemistry and morphological structure. The results are reported below.