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对３０例乳癌根治术患者术前、术毕及术后６、１２、２４、４８、７２小时各时相红细胞中的超氧化物歧化酶（ＳＯＤ）及血浆过氧化脂质（ＬＰＯ）的水平进行了测定。结果显示：乳癌患者红细胞ＳＯＤ含量与血浆ＬＰＯ水平呈显著负相关（ｒ＝－０．９０６４，ｔ检验Ｐ＜０．０１），术后血浆ＬＰＯ波动幅度及持续时间均大于红细胞ＳＯＤ；术毕皮瓣组织的ＳＯＤ下降，而ＬＰＯ上升，其差异显著（Ｐ＜０．０５）。推测其动态变化与血液中的变化相一致。此外，光镜见皮肤组织有嗜中性白细胞浸润，电镜观察显示皮肤微血管内皮损伤。作者认为，乳癌根治术后自由基产生增多导致微血管内膜损害是皮瓣坏死的重要原因。
The levels of superoxide dismutase (SOD) and plasma lipid peroxide (LPO) levels in red blood cells of 30 patients undergoing radical mastectomy before, after, and 6, 12, 24, 48, and 72 hours after operation Measurements were made. The results showed that the erythrocyte SOD content was significantly negatively correlated with plasma LPO levels in patients with breast cancer (r=-0.9064, t-test P<0.01). The amplitude and duration of postoperative plasma LPO were greater than that of erythrocyte SOD; The SOD of the flap tissue decreased while the LPO rose, the difference was significant (P<0.05). Presumably its dynamic changes are consistent with changes in the blood. In addition, light microscopy showed neutrophil infiltration in the skin tissue, and electron microscopy revealed microvascular endothelial damage. The authors believe that increased free radical production after radical mastectomy leads to microvascular intimal lesions as an important cause of flap necrosis.