Objective: To evaluate the enhancement characteristics of the hepatic parenchyma during scanning with computed tomography (CT) during splenoportography (CTSP). Methods.. Thirty patients refferred for CTSP were included in the study. Attenuation was measured at different time after contrast medium injection, and time-attenuation curves were created. Enhancement characteristics were evaluated, and the parenchyma-to-tumor difference of attenuation were compared. Results.. CTSP led to high parenchymal enhancement. The highest enhancement value in the left lobe was (218. 0±53. 2) Hu and (246.0± 60. 2) Hu in the right lobe. The difference between the right and left lobes was statistically significant (P＜0. 05); The parenchyma-to-tumor difference of (65.3± 25.6) Hu was observed during scanning after injection. Conclusion: The high levels of liver parenchymal enhancement and parenchyma-to-lesion contrast can be achieved within the scanning time with CTSP.