勃起功能障碍(ED)患者长期服用他达拉非的安全性和耐受性是保障患者受益的重要前提。他达拉非不良反应的产生主要来自他达拉非与PDE5及其同工酶的相互作用。治疗中出现不良事件多为轻度或中度,为一过性、可逆性,一般无需停药。它对心血管安全性良好,不会增加心血管事件的风险以及严重程度;与降压药以及选择性α受体阻滞剂合用时仍是安全的。 The long-term safety and tolerability of tadalafil in patients with erectile dysfunction (ED) is an important prerequisite for patient benefit. Adverse reactions to tadalafil mainly result from the interaction of tadalafil with PDE5 and its isoenzymes. Adverse events in treatment are mostly mild or moderate, transient, reversible, usually without stopping. It is safe for cardiovascular safety and does not increase the risk and severity of cardiovascular events; it remains safe with antihypertensives and selective alpha blockers.