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IL- 18是一种多效性的细胞因子 ,通过巨噬细胞、NK细胞和 T细胞产生其他抗肿瘤因子加强机体对肿瘤的免疫力 ,在抗肿瘤、免疫调节中受到广泛关注 ,将在临床应用中有重要价值。本文就 IL- 18及其基因在肿瘤治疗中的应用进展及其部分作用机制作一综述。
IL-18 is a pleiotropic cytokine that enhances the immunity of the tumor against macrophages, NK cells and T cells by other anti-tumor factors. It is widely concerned in antitumor and immunomodulation and will be widely used in clinic Application has important value. This article reviews the progress of IL-18 and its gene in the treatment of cancer and its partial mechanism of action.