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目的:分析某市辖区内医院患者26例左氧氟沙星注射液致不良反应症状的类型及其风险因素,为避免不良反应的发生提供参考。方法:采用回顾性分析法,抽取2016年1—12月期间某市辖区内医院使用左氧氟沙星注射液治疗患者670例临床资料,分析其左氧氟沙星注射液致不良反应的类型及风险因素。结果:使用左氧氟沙星注射液治疗患者670例中,26例发生不良反应占3.88%,主要症状涉及皮肤、消化系统、神经系统和呼吸系统等器官/系统;不良反应发生的主要风险因素与患者年龄和每日剂量、疗程、过敏药物种类和合并用药种类有关联(P<0.05)。结论:某市辖区内医院患者中,左氧氟沙星注射液致不良反应症状主要涉及全身各器官、系统,临床上应加强对该药的使用管理,并根据患者风险因素合理选用左氧氟沙星注射液治疗,以避免或杜绝不良反应的发生。
Objective: To analyze the types and risk factors of adverse reactions of 26 patients with levofloxacin in hospital area of a certain city, and provide reference for avoiding the occurrence of adverse reactions. Methods: The clinical data of 670 patients treated with levofloxacin injection in hospitals in a certain city area from January to December in 2016 were analyzed retrospectively. The types and risk factors of adverse reactions caused by levofloxacin injection were analyzed. RESULTS: Of the 670 patients treated with levofloxacin injection, 26 patients had adverse reactions accounting for 3.88%. The main symptoms involved organs, such as the skin, digestive system, nervous system and respiratory system. The main risk factors for adverse reactions were age-related The daily dose, duration of treatment, type of allergy medication and the type of drug combination were associated (P <0.05). Conclusion: The adverse reactions caused by levofloxacin injection in hospital area of a certain city mainly involve all organs of the body, and the administration of this medicine should be strengthened systematically and systematically, and levofloxacin injection should be rationally selected according to the patient’s risk factors to avoid Or eliminate the occurrence of adverse reactions.