论文部分内容阅读
目的：在实验犬中观察多沙普仑、多巴胺对失血性休克等容输血后血流动力学的影响，探索多涉普仑对失血性休克等容输血后血流动力学产生良性影响的作用机制。方法：实验犬分对照组、多沙普仑组和多巴胺组，每组5条。三组动物均于股动脉快速放血30ml/kg，造成严重失血性休克模型，30分钟后等容输血。多沙普仑组于输血后立即静脉注射多沙普仑2mg／kg，多巴胺组于输血后立即静脉输注多巴胺8ug/kg/min.采用Swan-Ganz漂浮导管及心脏电脑监护仪等手段分别于动物休克、等容输血前后测定血流动力学参数。结果：休克5分钟和30分钟，三组动物的MAP、CO、CI、SV、LVSW、LVSWI明显下降，SVR明显增高；等容输血后15分钟三组动物的上述参数均有所恢复，多沙普仑组和多巴胺组都恢复至休克前水平，两组之间差异也无统计学意义，但对照组则未能恢复。结论：多沙普仑对失血性休克等容输血后血流动力学的良性影响与多巴胺相似，其作用机制可能与多沙普仑刺激机体释放多巴胺有关。
OBJECTIVE: To observe the effects of doxapram and dopamine on hemodynamics after isoproterenol transfusion in hemorrhagic shock in experimental dogs and to explore the effect of polyunsulpride on hemodynamics after hemorrhagic shock isovolumic transfusion mechanism. Methods: The dogs were divided into control group, doxapram group and dopamine group, with 5 in each group. Three groups of animals in the femoral artery rapid bleeding 30ml / kg, causing severe hemorrhagic shock model, isovolumic transfusion after 30 minutes. In the doxapram group, doxapram 2 mg / kg was injected intravenously immediately after transfusion, and dopamine 8ug / kg / min was given intravenously immediately after transfusion in the dopamine group. Swan-Ganz floating catheter and cardiac computer monitor Animal shock, hemodynamic parameters before and after isovolemic transfusion. Results: At 5 minutes and 30 minutes of shock, the MAP, CO, CI, SV, LVSW and LVSWI of the three groups were significantly decreased and the SVR was significantly increased. The parameters of the three groups of animals were recovered 15 minutes after isovolemic transfusion, Prelumbola group and dopamine group were restored to the pre-shock level, the difference between the two groups was not statistically significant, but the control group failed to recover. CONCLUSION: The positive effect of doxapram on hemodynamics after hemorrhagic shock isovolumic transfusion is similar to that of dopamine, which may be related to the effect of doxapram on dopamine release.