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目的比较系统性红斑狼疮患者(systemic lupus erythematosus,SLE)和正常对照者白细胞介素9(in-terleukin 9,IL-9)基因的2个单核苷酸多态性(single nucleotide polymorphism,SNP)位点(rs1859430,rs2069868)的等位基因的差异以及基因型频率的差异,从而探讨IL-9基因单核苷酸多态性与SLE的相关性。方法采用病例对照的研究,应用TaqMan基因分型技术,检测研究对象的基因单核苷酸多态性。结果两个SNP位点(rs1859430,rs2069868)的等位基因和基因型频率在正常对照组和SLE患者组的差异均无统计学意义(均有P>0.05),狼疮肾炎患者组(lupus nephritis,LN)和非狼疮肾炎患者组(non-lupus nephritis,Non-LN)的分布差异均无统计学意义(均有P>0.05)。结论未发现IL-9基因的rs1859430和rs2069868位点的多态性与中国汉族人群的易感性有关。
Objective To compare the polymorphisms of two single nucleotide polymorphisms (SNPs) in patients with systemic lupus erythematosus (SLE) and normal controls with in-terleukin 9 (IL-9) (Rs1859430, rs2069868) alleles and genotype frequency differences, so as to explore IL-9 gene single nucleotide polymorphisms and SLE correlation. Methods A case-control study was conducted to detect single nucleotide polymorphisms of the target gene using TaqMan genotyping technique. Results The allele and genotype frequency of two SNP loci (rs1859430, rs2069868) were not significantly different between the normal control group and the SLE patients (all P> 0.05). The incidence of lupus nephritis There was no significant difference in the distribution of non-LN (LN) and non-LN (all P> 0.05). Conclusion No polymorphisms of rs1859430 and rs2069868 in IL-9 gene were found to be associated with susceptibility to Chinese Han population.