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目的探讨胸腔积液生化测定中,增设腺苷脱氨酶(ADA)、癌胚抗原(CEA)在胸腔积液性质鉴别中的临床应用价值。方法将115例胸腔积液患者,按临床诊断依据分为炎性组、结核组、恶性组,分别测定其胸水/血清的ADA和CEA含量。结果结核组胸水和血清中的ADA含量明显高于恶性组和炎性组,两组间比较差异具有统计学意义(P<0.01)。恶性组胸水及血清CEA含量明显高于结核组和炎性组,两组间比较差异具有统计学意义(P<0.01)。结论在检测中增加以上两个项目后,有助于临床医生对胸腔积液性质的鉴别,形成的原因及对相关部位疾病的诊断,为临床提供更科学、更有实际意义的实验室诊断依据。
Objective To investigate the clinical value of adding adenosine deaminase (ADA) and carcinoembryonic antigen (CEA) in the differential diagnosis of pleural effusion in pleural effusion biochemical assay. Methods One hundred and fifteen patients with pleural effusion were divided into inflammatory group, tuberculosis group and malignant group on the basis of clinical diagnosis. The contents of ADA and CEA in pleural effusion / serum were determined respectively. Results The pleural effusion and serum ADA levels in tuberculosis group were significantly higher than those in malignant and inflammatory groups, with significant difference between the two groups (P <0.01). Malignant pleural effusion and serum CEA levels were significantly higher than the tuberculosis group and inflammatory group, the difference between the two groups was statistically significant (P <0.01). Conclusions After the above two items are added to the test, it is helpful for clinicians to identify the cause of pleural effusion, diagnose the disease and provide a more scientific and practical laboratory diagnosis basis .