论文部分内容阅读
人类随着年龄的增长，肾上腺分泌的雄激素，去氢表雄酮（ＤＨＥＡ）和ＤＨＦＡ硫酸盐（ＤＳ），与生长激素－胰岛素－类生长因子－Ⅰ（ＧＨ－ＩＧＦ－Ｉ）轴的分泌平行性减少。尽管人们对ＧＨ－ＩＧＦ－Ｉ系统的衰退与分解代谢的功能关系亦有所认识，但对ＤＨＥＡ在人类年龄增长中的生理作用仍不清楚。为了证实随年龄的增长，ＤＨＥＡ下降可能也参与从合成代谢转向分解代谢这个假设，我们对１３名男性，１７名女性，年龄４０～７０岁，进行补充剂量ＤＨＥＡ作用的研究，用随机交换服用安慰剂的方式，每晚口服ＤＨＥＡ５０ｍｇ６个月。在治疗期间测定雄激素、脂类、阿朴脂蛋白、ＩＧＦ－Ｉ、ＩＧＦ－结合蛋白－１（ＩＧＦＢＰ－１）及ＩＧＦＢＰ－３浓度，衡量胰岛素敏感性、体内脂肪比率、性欲和自我感觉。一小组男性（ｎ＝２８），女性（ｎ＝５）进行了２４小时内每隔２０分钟取血标本测定ＧＨ。补充ＤＨＥＡ２周，血清ＤＨＥＡ和ＤＳ水平恢复到青年状态，并维持到３个月的研究期。在女性血中，雄激素（雄稀二酮，睾酮和去氢睾酮）增加２倍，而男性仅有雄稀二酮少量升高。在两性中，性激素结合球蛋白雌酮或雌二醇均无改变。女性高密度脂蛋白稍有下降，两性其它脂类无改变，胰岛素敏感性和体内脂肪比率?
With age, adrenal secretion of androgens, dehydroepiandrosterone (DHEA) and DHFA sulfate (DS), and secretion of the growth hormone-insulin-like growth factor-I (GH-IGF-I) Parallelism decreases. Although the functional relationship between the decline of the GH-IGF-I system and catabolism is also known, the physiological role of DHEA in human age growth remains unclear. To confirm that the decline in DHEA may also be involved in the shift from anabolism to catabolism with age, we conducted a study of supplemental DHEA in 13 males and 17 females, aged 40- 70 years, with comfort in random exchange The way, every night oral DHEA50mg6 months. The concentrations of androgens, lipids, apolipoproteins, IGF-I, IGF-binding protein-1 (IGFBP-1) and IGFBP-3 were measured during treatment to measure insulin sensitivity, body fat ratio, libido and self-perception. A small group of males (n = 28) and females (n = 5) performed GH determinations every 20 minutes within 24 hours. After 2 weeks of DHEA supplementation, serum DHEA and DS levels returned to youth status and remained within the 3-month study period. In women’s blood, androgens (androsodione, testosterone and dehydrogenated testosterone) increased 2-fold, while men only had a small increase in maleated diketones. In both sexes, sex hormone binding globulin estrone or estradiol were unchanged. Female high-density lipoprotein decreased slightly, no change in other lipids of both sexes, insulin sensitivity and body fat ratio?