论文部分内容阅读
亲吻素(kisspeptins)是由KiSS-1基因编码的一组多肽激素,与其受体GPR54一起组成KiSS-1/GPR54系统,参与下丘脑-垂体-性腺轴功能的调节,并在青春期启动和促性腺素释放过程中发挥非常重要的作用。在人和许多动物中研究显示:KiSS-1基因在下丘脑的特定部位表达,并受到性激素的调节。由此人们推测,性激素,特别是雌激素,可能是通过KiSS-1/GPR54系统将其反馈信号传递到GnRH神经元,导致排卵前GnRH/LH峰的形成。本文主要对KiSS-1基因及其编码蛋白的分子结构,KiSS-1/GPR54系统的信号转导途径及其对性腺轴功能的调节机制进行介绍,以期为从事生殖基础医学研究的科研人员提供有益的参考。
Kisspeptins, a group of polypeptide hormones encoded by the KiSS-1 gene, together with its receptor GPR54, form the KiSS-1 / GPR54 system, which is involved in the regulation of hypothalamic-pituitary-gonadal axis function and promotes puberty and gonadal activation The release of the prime plays a very important role. Studies in humans and many animals show that the KiSS-1 gene is expressed at specific sites in the hypothalamus and is regulated by sex hormones. It is speculated that sex hormones, estrogen in particular, may transmit their feedback signals to GnRH neurons via the KiSS-1 / GPR54 system, resulting in the formation of preovulatory GnRH / LH peaks. This article mainly introduces the molecular structure of KiSS-1 gene and its encoded protein, the signal transduction pathway of KiSS-1 / GPR54 system and its regulatory mechanism of gonadal axis function, in order to provide useful information for researchers engaged in reproductive basic medical research The reference.