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Objective:The aim of the study was to explore the therapeutic efficacy and safety of batroxobin in patients with primary hepatic carcinoma(PHC)and the advantages of transcatheter arterial perfusion of batroxobin combined with transcatheter arterial chemoembolization(TACE).Methods:Forty patients with PHC were randomized into experimental group(transcatheter arterial perfusion of batroxobin combined with TACE treatment,20 patients)and control group(TACE alone group,20 patients).The patients were followed up and the data were recorded,compared and analyzed.Results:(1)Compared with the control group,the FIB level in the experimental group was significantly decreased at the first month after treatment(P<0.05).(2)The baseline of the tumor was shortened in both groups after the treatment.There was a significant difference between the two groups at different time intervals(P<0.05).(3)After the treatment,there was a significant difference of progression-free survival(PFS)levels between the two groups(t=2.877,P0.05).Conclusion:Batroxobin can rapidly and effectively decrease the FIB level of the PHC cases.Therefore it may be used as an effective and safe adjuvant drug for the treatment of primary hepatic carcinomas.Transcatheter arterial perfusion of batroxobin combined with TACE therapy has advantages in comparison with TACE alone therapy.It could be taken as a new therapeutic regimen in the PHC treatment.