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目的探讨广东地区近年在产前诊断中常染色体三体检出率的变化情况和原因。方法对2005年至2007年和2008年至2010年两个时间段因各种产前诊断指征在本院行胎儿染色体核型分析的病例的常染色体三体检出率进行比较。结果在产前诊断中21-三体、18-三体和13-三体是最常见的常染色体三体;2008年至2010年的常染色体三体总检出率和高龄孕妇比例比2005年至2007年提高;两个时间组非高龄孕妇妊娠常染色体三体儿几率均高于高龄孕妇。结论广东地区近年产前诊断常染色体三体总检出率的提高与孕妇高龄化、环境污染、孕期血清学筛查和超声检查的广泛应用有关,提高医务人员的检验水平和保护环境有助于减少常染色体三体儿的出生。
Objective To investigate the changes and the causes of autosomal trisomy in prenatal diagnosis in Guangdong in recent years. Methods The detection rates of autosomal trisomy in cases of fetal karyotype analysis in our hospital from 2005 to 2007 and from 2008 to 2010 for various prenatal diagnosis indications were compared. Results In prenatal diagnosis, 21-trisomy, 18-trisomy and 13-trisomy were the most common autosomal trisomy. The total autosomal trisomy and the proportion of pregnant women in the period from 2008 to 2010 were higher than those in 2005 To improve in 2007; two groups of non-pregnant women with gestational autosomal dominant trisomy were higher than the older pregnant women. Conclusion The increase of antenatal tachycardia trisomy in Guangdong in recent years is related to the extensive application of pregnant women’s aging, environmental pollution, serological screening during pregnancy and ultrasonography. It is helpful to improve the level of medical personnel’s examination and protect the environment Reduce the birth of autosomal trisomy.