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合成了一系列含有平面配体的Cu髤多吡啶配合物[Cu(IP)2]2+、[Cu(PIP)2]2+、[Cu(DPPZ)2]2+和[Cu(HPIP)2]2+,用吸收光谱、CD光谱和粘度等方法研究了这些配合物与小牛胸腺DNA的作用。结果表明配体上的取代基及配体的平面性对这些四面体配合物与DNA的结合强弱产生一定的影响。[Cu(DPPZ)2]2+与DNA的结合较强,而[Cu(HPIP)2]2+与DNA的结合较弱。CD光谱显示配合物[Cu(DPPZ)2]2+、[Cu(PIP)2]2+和[Cu(HPIP)2]2+的加入会导致DNA的CD光谱减弱。而[Cu(IP)2]2+的加入则会使DNA的CD光谱增强。同时,[Cu(IP)2]2+与DNA结合后,还会引起一定程度的DNA构型转换,即DNA从B型转换成Z型。
A series of Cu 髤 polypyridyl complexes [Cu (IP) 2] 2 +, [Cu (PIP) 2] 2 +, [Cu (DPPZ) 2] 2+ and [Cu (HPIP) 2] 2+, the effects of these complexes on calf thymus DNA were studied by absorption, CD spectra and viscosity. The results show that the substituents on the ligands and the planarity of the ligand have an impact on the binding strength of these tetrahedral complexes to DNA. The binding of [Cu (DPPZ) 2] 2+ to DNA is strong, while the binding of [Cu (HPIP) 2] 2+ to DNA is weak. The CD spectra showed that the addition of Cu (DPPZ) 2] 2 +, [Cu (PIP) 2] 2+ and [Cu (HPIP) 2] 2+ resulted in a weakening of the CD spectrum of DNA. The addition of [Cu (IP) 2] 2+ enhanced the CD spectra of DNA. At the same time, the binding of [Cu (IP) 2] 2+ to DNA also leads to a certain degree of DNA conformational transition, ie the conversion of DNA from B type into Z type.