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目的:探讨辛伐他汀40mg/d短期(24周)治疗外周动脉疾病引起的间歇性跛行患者踝臂指数(ABI)和6min步行试验(6-MWT)改变情况。方法:将62例外周动脉疾病下肢跛行患者随机分为常规治疗组(31例)和辛伐他汀组(31例),治疗前后分别检测血脂、ABI和6-MWT。结果:辛伐他汀组血脂、ABI和6-MWT治疗前后差异有统计学意义,而常规治疗组差异无统计学意义。结论:辛伐他汀40mg/d对ABI低于0.9的间歇性跛行患者短期(24周)治疗后,能明显提高患者的ABI值,能增加患者6-MWT步行距离,改善患者日常活动能力。
Objective: To investigate the changes of ankle brachial index (ABI) and 6-minute walking test (6-MWT) in patients with intermittent claudication caused by simvastatin 40 mg / d for 24 weeks. Methods: Sixty-two cases of peripheral arterial limp limpid patients were randomly divided into routine treatment group (n = 31) and simvastatin group (n = 31). Blood lipid, ABI and 6-MWT were measured before and after treatment. Results: There was significant difference between the simvastatin group before and after the treatment of serum lipids, ABI and 6-MWT, but there was no significant difference in the routine treatment group. Conclusion: Simvastatin 40 mg / d for ABI less than 0.9 in patients with intermittent claudication after a short-term (24 weeks) treatment can significantly improve the ABI value in patients with 6-MWT can increase the walking distance and improve patients with daily activities.