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为评价反映儿童锌缺乏的敏感指标.方法 我们对300名3～6岁儿童进行膳食调查与体格检查,同时测定了锌缺乏组和对照组儿童的尿锌与尿肌酐比值,血清ALP活性,血清胆固醇水平及锌缺乏儿童补锌治疗前后上述指标的变化.结果 锌缺乏组与对照组尿锌与尿肌酐比值,血清ALP活性有显著性差异.锌缺乏组儿童血浆锌,尿锌与尿肌酐比值,血清ALP活性,血清胆固醇水平在补锌治疗前后有显著性差异.结论 血浆锌和血清ALP同时降低可以预示儿童体内锌缺乏,需要补锌治疗;尿锌与尿肌酐比值能较敏感地反映儿童的锌营养状况;胆固醇与锌营养之间的关系值得进一步研究.
To evaluate the sensitivity of zinc deficiency in children.Methods We conducted a dietary survey and physical examination of 300 children aged 3 to 6 years old.At the same time we measured the urinary zinc to urinary creatinine ratio, serum ALP activity, Cholesterol and zinc deficient children before and after zinc supplementation.Results The ratios of urinary zinc to urinary creatinine and the serum ALP activity in zinc deficient group and control group were significantly different.Compared with zinc deficient group, the ratios of plasma zinc, urinary zinc and urinary creatinine , Serum ALP activity and serum cholesterol levels were significantly different before and after the treatment with zinc.Conclusion The simultaneous reduction of plasma zinc and serum ALP can predict the zinc deficiency in children and require zinc supplementation.The ratio of urinary zinc and urinary creatinine can reflect the sensitivity of children Zinc nutritional status; the relationship between cholesterol and zinc nutrition warrants further study.