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血管形成在肿瘤发生、发展中起重要作用,血管内皮生长因子(VEGF)可特异性促进生成新血管,在多种肿瘤组织中高表达。故VEGF在食管癌生长和转移过程中起重要作用,并与食管癌预后密切相关。目前靶向VEGF及其受体的肿瘤治疗已取得很大进展。本文就近年VEGF与食管癌的研究进展作一综述。
Vascular formation plays an important role in tumorigenesis and development. Vascular endothelial growth factor (VEGF) can specifically promote the formation of new blood vessels and is highly expressed in many tumor tissues. Therefore, VEGF plays an important role in the growth and metastasis of esophageal cancer and is closely related to the prognosis of esophageal cancer. At present, great progress has been made in the treatment of tumors that target VEGF and its receptors. This article reviews the progress of VEGF and esophageal cancer in recent years.