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目的:对脓毒症患儿65例的临床分析,了解此种疾病的临床特点,为临床诊断及治疗提供参考。方法:对2011年1月-2016年1月我院收治的65例脓毒症患儿的临床表现,基础疾病,炎性指标,病原菌及其耐药性进行分析。结果 :1-2岁者有41例,所占比例为63.1%,有26例伴有基础疾病,所占比例为40.0%,其中血液系统及营养不良者所占比例较高;65例患儿共检出85株病原菌,以G-为主,所占比例为54.1%,G+以金黄色葡萄球菌为主,真菌检出率为4.7%;病原菌对头孢类及沙星类抗菌药物敏感性较低,对美罗培南敏感性较高;患儿的白细胞总数、C反应蛋白和降钙素原指标均显著高于正常者。结论 :脓毒症患儿以1-2岁为主,一部分患儿伴有基础疾病,病原菌对头孢类及沙星类抗菌药物敏感性较低,炎性指标水平异常。
Objective: To analyze the clinical characteristics of 65 cases of sepsis in children and understand the clinical features of this disease, providing reference for clinical diagnosis and treatment. Methods: The clinical manifestations, underlying diseases, inflammatory indexes, pathogenic bacteria and drug resistance of 65 children with sepsis admitted in our hospital from January 2011 to January 2016 were analyzed. Results: There were 41 cases in 1-2 years old, accounting for 63.1%, 26 cases were associated with underlying diseases, accounting for 40.0%, of which the blood system and malnutrition accounted for a higher proportion; 65 cases A total of 85 pathogenic bacteria were detected, accounting for 54.1% of the total, with Staphylococcus aureus being dominant in G +, and the detection rate of fungi was 4.7%. The sensitivity of pathogens to cephalosporins and sand star antibiotics was more Low, high sensitivity to meropenem; children with leukocytes, C-reactive protein and procalcitonin indicators were significantly higher than normal. Conclusions: The children with sepsis are 1-2 years old. Some patients have underlying diseases. The pathogenic bacteria are less sensitive to cephalosporins and non-steroidal anti-bacterial drugs and the inflammatory markers are abnormal.