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目的 研究脑梗死患者血清 IL - 6含量变化及其意义。方法 我们用双抗体夹心 EL ISA法对 30例脑梗死患者的血清分别在发病 1d、3d、7d进行了连续检测 ,并用 2 0例健康人作对照。结果 发现脑梗死患者血清 IL -6含量在 3个时间点均高于对照组 (P<0 .0 5 )。在病程第 1d血清 IL- 6含量高于第 3d和第 7d(P<0 .0 5 ) ,且大面积脑梗死组血清 IL- 6含量高于小面积脑梗死组 ,神经功能受损重者血清 IL- 6含量高于神经功能受损轻者 (P<0 .0 5 )。结论 IL- 6在脑梗死中起重要作用 ,且 IL- 6水平与脑梗死面积、神经功能受损程度呈正相关。
Objective To study the changes of serum IL - 6 in patients with cerebral infarction and its significance. Methods Serum samples from 30 patients with cerebral infarction were detected continuously on the first day, the third day and the seventh day respectively by the double antibody sandwich ELISA method. Twenty healthy controls were used as controls. The results showed that serum IL-6 levels in patients with cerebral infarction were higher than those in the control group at 3 time points (P <0.05). Serum levels of IL-6 on the first day were higher than those on the third and seventh days (P <0.05), and the IL-6 levels in the large area cerebral infarction group were higher than those in the small area cerebral infarction group Serum IL-6 levels higher than those with mild impaired neurological function (P <0.05). Conclusion IL-6 plays an important role in cerebral infarction, and the level of IL-6 is positively correlated with the infarction area and the impaired neurological function.