同型半胱氨酸(homocysteine,Hcy)是一种含硫基的非必需氨基酸,为蛋氨酸代谢的一个重要代谢产物,其代谢异常可导致高同型半胱氨酸血症,对内皮细胞产生毒性作用及凝血和促凝血等作用。内皮细胞激活和损伤是妊娠期高血压疾病发病的主要原因。升高的同型半胱氯酸通过损伤内皮细胞,导致血管痉挛收缩,体液蛋白外渗及血管内凝血等机制参与妊娠期高血压疾病的发生。 Homocysteine ​​(Hcy) is a sulfur-containing non-essential amino acids, methionine metabolism is an important metabolite, the metabolic abnormalities can lead to hyperhomocysteinemia, toxic effects on endothelial cells And coagulation and procoagulant role. Endothelial cell activation and injury are the main causes of hypertensive disorders during pregnancy. Elevated homocysteine ​​is involved in the development of hypertensive disorder complicating pregnancy by damaging the endothelial cells, causing vasospasm contraction, extravasation of humoral proteins and intravascular coagulation.