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把1985年1月4日～1988年3月25日间需择期行经腹结直肠手术的197例病人(男126,女71),随机分为治疗组(101例)和对照组(96例)。对照组术前进行标准的机械性肠道准备和口服抗生素(新霉素和红霉素),治疗组在此基础上加用3次头孢西丁每次非经肠给予2克,第一次在术前60min,第2次在术后6h,第3次在此后的6h。结果:伤口感染在对照组有14例(14.6%治疗组5例(5%),差别显著(p=0.02)。吻合口漏在对照组78个中有4个(5.1%),治疗组89个中有3个(3.4%),但无统计学意义(p=0.67).盆腔脓肿在对照组为2例(2%)。
A total of 197 patients (male 126, female 71) who underwent elective abdominal surgery during January 4, 1985 to March 25, 1988 were randomly divided into treatment group (n = 101) and control group (n = 96) . The control group received standard mechanical enteral preparation and oral antibiotics (neomycin and erythromycin) preoperatively. On the basis of this, the treatment group added cefoxitin 3 times twice daily for parenteral administration. The first time Sixty minutes before surgery, the second at 6 hours after surgery and the third at 6 hours thereafter. RESULTS: Fourteen cases (14.6%) had wound infection in the control group (5%, 5%), with a significant difference (p = 0.02). Anastomotic leakage was found in 4 of 78 controls (5.1% There were 3 (3.4%) of them, but not statistically significant (p = 0.67). Pelvic abscess was found in 2 (2%) patients in the control group.