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药物的物理化学性质及栓剂基质的特性是影响栓剂中药物吸收的重要因素,主药的粒径、水溶性、分配系数、解离常数和浓度,以及基质的组成、熔点、粘度、极性和延展性也是影响吸收的主要参数,而主药的理化常数决定于它的分子结构。本文用天然膜代替一般用的赛璐玢来研究不同亲脂和亲水侧链所组成的吡唑酮核药物从栓剂中的扩散速率,选择保泰松、羟基保泰松、苯磺唑酮和安替比林(以下分别简称A、B、C、D)为试验药物,用家兔进行体内试验来研究体内外的相关性。
The physicochemical properties of the drug and the properties of the suppository matrix are important factors that influence the absorption of the drug in the suppository. The particle size, water solubility, partition coefficient, dissociation constant and concentration of the drug, as well as the composition, melting point, viscosity, polarity and Ductility is also the main parameter that affects absorption, and the physicochemical constant of the main drug depends on its molecular structure. In this paper, the natural membrane instead of the general use of cellophane to study different lipophilic and hydrophilic side chain consisting of pyrazole ketone nucleus drugs from the suppository diffusion rate, the selection of phenylbutazone, hydroxy phenylbutazone, And antipyrine (hereinafter referred to as A, B, C, D respectively) were used as experimental drugs, and in vivo experiments in rabbits were conducted to study the correlation in vitro and in vivo.