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目的初步研究感音神经性聋患者短纯音刺激失匹配负波(mismatch negativity,MMN)的变化特征。方法采用美国32导Neuroscan EEG/ERP记录系统对24例(48耳)听力正常受试者和7例(14耳)感音神经性聋患者进行MMN测试。采用经典Oddball模式,标准刺激和偏差刺激分别为500Hz和1000Hz的短纯音测试两组受试者MMN,比较两组MMN潜伏期和波幅的差异。结果感音神经性聋组MMN潜伏期为145.00±16.11ms,与对照组130.45±7.31ms相比,明显延长(P=0.009),两组的波幅改变无统计学意义(P=0.908)。而两组的波幅变异系数(CV%)均大于对应潜伏期的变异系数(CV%)。结论感音神经性聋患者MMN的潜伏期明显延长,波幅变化不大。MMN潜伏期相对比较稳定,但波幅个体间差异较大。
Objective To study the changes of short tone tone mismatch negativity (MMN) in patients with sensorineural hearing loss. Methods MMN test was performed in 24 hearing-impaired subjects (48 ears) and 7 patients (14 ears) with sensorineural hearing loss using the American 32-lead Neuroscan EEG / ERP recording system. The classic Oddball model was used to measure the MMN latency and amplitude differences between the two groups using both standard stimulation and bias stimulation of short pure tone at 500 Hz and 1000 Hz, respectively. Results The latent period of MMN in patients with sensorineural hearing loss was 145.00 ± 16.11 ms, which was significantly longer than that in control group (P = 0.009). The amplitude of MMN was no significant difference between two groups (P = 0.908). The coefficient of variation (CV%) of the two groups were greater than the coefficient of variation (CV%) of the corresponding incubation period. Conclusion The latent period of MMN in patients with sensorineural deafness was significantly prolonged, with little change in amplitude. MMN latency is relatively stable, but the amplitude of individual differences.