在迄今已筛选过的数千株微生物中,只有少数几株具有抗蠕虫活性。1978年Burg等在以管饲法感染线虫(Nematospiroides dubius)的Charlar River CD-1雄性小白鼠上,连续6天给以混合放线菌发酵液的饲料,于14天时观察蠕虫卵的减少。根据这一方法他们从日本Kawana采集的土样中筛出一株放线菌,其发酵液具有很强的抗蠕虫活性,至少在常用剂量 Of the thousands of microorganisms that have been screened to date, only a few have anthelmintic activity. In 1978, Burg et al., On a Charlar River CD-1 male mouse gavaged with Nematospiroides dubius, were given a feed of mixed actinomycete broth for 6 consecutive days and the reduction of worm eggs was observed at 14 days. According to this method, they screened an actinomycete from soil samples collected from Kawana, Japan. The fermentation broth has a strong anti-worm activity, at least at the usual dosage