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以二氧六环/水为溶剂体系,以聚己内酯(PCL)和聚乙烯吡咯烷酮(PVP)为原料,采用相分离法制备纳米纤维支架,研究了陈化、溶剂比例和PVP含量对支架的纳米纤维结构形成的影响,以及PVP的添加对支架生物活性和亲水性能的影响。结果表明,陈化直接影响纳米纤维网络结构的形成;溶剂体系和PVP含量均影响纳米纤维结构,随着PVP含量的提高纳米纤维结构逐渐消失。随着PVP含量的提高,支架的亲水性能提高。PVP/PCL复合纳米纤维支架浸泡模拟体液(SBF)后在其内部和表面皆生成碳磷灰石(CHA)涂层,表明该纳米纤维支架具有良好的生物活性,且PVP/PCL支架比纯PCL支架能更快诱导生成碳磷灰石。
The nanofiber scaffolds were prepared by phase separation using polycaprolactone (PCL) and polyvinylpyrrolidone (PVP) as raw materials in dioxane / water as solvent system. The effects of aging, solvent ratio and PVP content on the scaffold The effect of PVP on the bioactivity and hydrophilicity of scaffolds was also investigated. The results showed that aging directly affected the formation of nanofibrous network structure. Both solvent system and PVP content affected the structure of nanofibers. With the increase of PVP content, the nanofiber structure gradually disappeared. As the PVP content increases, the hydrophilicity of the scaffold increases. The PVA / PCL composite nanofibrous scaffold soaked in simulated body fluid (SBF) produced a coating of carbon apatite (CHA) both inside and on the surface, indicating that the nanofibrous scaffold has good biological activity, and the PVP / PCL scaffold is better than pure PCL Scaffolds induce faster formation of carbon apatite.