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作者对34例恶性间皮瘤和40例生长活跃的间皮细胞用免疫组化方法进行鉴别并进行统计比较分析。恶性间皮瘤阳性标记有胰岛素样生长因子2、信使RNA结合蛋白3(IMP3)、葡萄糖载体1(GLUT1)、上皮膜抗原(EMA)、CD146,4种抗体的敏感性分别是94%、85%、79%、和71%,特异性分别是78%、100%、88%和98%。在恶性间皮瘤中,EMA的表达明显低于IMP3、GLUT和CD146(P<0.001)。ROC曲线(受试者工作特性曲线)面积,IMP3最高,为0.95,GLUT1其次,为0.93。结合最佳拐点,IMP3(30%)和GLUT
The author of 34 cases of malignant mesothelioma and 40 cases of active mesothelial cells were identified by immunohistochemistry and statistical analysis. Malignant mesothelioma positive labeled insulin-like growth factor 2, messenger RNA binding protein 3 (IMP3), glucose carrier 1 (GLUT1), epithelial membrane antigen (EMA), CD146, 4 kinds of antibody sensitivity were 94%, 85 %, 79%, and 71% with specificity of 78%, 100%, 88% and 98%, respectively. In malignant mesothelioma, EMA expression was significantly lower than IMP3, GLUT and CD146 (P <0.001). The area of the ROC curve (receiver operating characteristic curve), IMP3 highest, was 0.95, GLUT1 followed by 0.93. Combined with the best inflection point, IMP3 (30%) and GLUT