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Rotavirus is the most common etiologic agent of severe diarrhea in infants and young children and causes more than 200,000 deaths annually worldwide [1,2].Licensed rotavirus vaccines can provide more than 50% protection against rotavirus infection, and currently available etiological treatments for rotavirus gastroenteritis mainly involve the use of oral rehydration solution and zinc supplementation [3].However, targeted interventions are in great need for rotavirus-induced gastroenteritis control.