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目的 研究OLC1蛋白在乳腺浸润性导管癌中的表达及其临床意义.方法 采用免疫组化检测79例乳腺浸润性导管癌组织和30例癌旁乳腺组织中OLC1蛋白的表达,并分析其表达与患者临床病理特征的关系.结果 OLC1蛋白在79例乳腺浸润性导管癌组织中的阳性率为51.9％(41/79),在30例癌旁乳腺组织中的阳性表达率为13.3％(4/30),差异有统计学意义(P＜0.05);OLC1在乳腺浸润性导管癌组织中的表达与肿瘤大小、组织学分级、TNM分期及有无淋巴结转移显著相关(P＜0.05).结论 OLC1可能在乳腺浸润性导管癌的发生和发展中起重要作用,可作为临床诊断的辅助标记物.“,”Objective To explore the expressions and clinical significance of OLC1 in infiltrating ductal breast cancer.Methods The expressions of OLC1 in 79 cases of infiltrating ductal breast cancer tissues and 30 cases of corresponding non-tumor breast tissues were detected by immunohistochemistry (IHC),and its correlation with clinicopathological characteristics was further elucidated.Results The positive rate of OLC1 was 51.9％ (41/79) in 79 cases of infiltrating ductal breast cancer,while 13.3％ (4/30) in corresponding non-tumor breast tissues;the difference was significant (P ＜ 0.05).OLC1 expression in infiltrating ductal breast cancer tissues was significantly correlated with tumor size,histological grade,TNM staging and lymph node metastasis (P ＜ 0.05).Conclusion The expression of OLC1 may contribute to the occurrence and development in infiltrating ductal breast cancer.