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目的研究对比治疗新生黄疸患儿时使用LED冷光源与常规蓝光光疗的治疗效果及其副作用。方法 60例新生黄疸患儿,根据随机对照、平行、单盲的原则将其分为对照组和观察组,各30例。对照组接受常规蓝光光疗治疗,观察组则接受LED冷光源治疗,观察对比两组患儿治疗后的血清总胆红素情况、胆红素结构异构体以及不良反应发生率。结果观察组的血清总胆红素为(196.3±14.4)μmol/L,对照组的血清总胆红素为(199.1±17.8)μmol/L,比较差异无统计学意义(P>0.05);观察组的胆红素结构异构体为(11.1±1.2)μmol/L,对照组的胆红素结构异构体为(10.9±1.3)μmol/L,比较差异无统计学意义(P>0.05);观察组患儿烦躁哭闹、发热、腹泻、皮疹、低血钙、脱水等不良反应发生率显著低于对照组,差异有统计学意义(P<0.05)。结论在新生黄疸患儿的治疗过程中,LED冷光源治疗能够保证退黄效果,而且由于不含红外线和紫外线,因此患儿的不良反应发生率更低,预后更佳,值得推广应用。
Objective To compare the therapeutic effects and side effects of using LED cold light source with conventional blue light therapy in neonates with jaundice. Methods Sixty newborns with jaundice were randomly divided into control group and observation group according to the principle of randomized control, parallel and single blind, each 30 cases. The control group received routine Blu-ray phototherapy, while the observation group received cold LED light source treatment. The levels of serum total bilirubin, bilirubin isoforms and the incidence of adverse reactions were compared between the two groups. Results The serum total bilirubin in the observation group was (196.3 ± 14.4) μmol / L, while the total serum bilirubin in the control group was (199.1 ± 17.8) μmol / L, with no significant difference (P> 0.05) (11.1 ± 1.2) μmol / L for bilirubin and 10.9 ± 1.3 μmol / L for bilirubin in the control group, with no significant difference (P> 0.05) The incidence of adverse reactions such as irritability, crying, fever, diarrhea, rash, hypocalcemia and dehydration in observation group was significantly lower than that in control group (P <0.05). Conclusion In the treatment of neonatal jaundice, LED cold light therapy can ensure the efficacy of jaundice, and because of no infrared and ultraviolet rays, the incidence of adverse reactions in children is lower and the prognosis is better, which is worth popularizing and applying.