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登革病毒属黄病毒属 ,可造成致死性登革出血热 /登革热休克综合征。目前尚无登革病毒疫苗 ,因此急需研制能针对所有 4个型登革病毒的安全有效的疫苗。在此作者报告了重组 2型登革病毒 E蛋白 (r Egp)的产生、纯化及对小鼠的免疫原性。 从感染 2型登革病毒的细胞培养上清中提
Dengue virus genus flavivirus can cause lethal dengue hemorrhagic fever / dengue shock syndrome. There is currently no dengue virus vaccine and there is an urgent need to develop a safe and effective vaccine against all four types of dengue virus. Here, the authors report the generation, purification and immunogenicity of recombinant dengue virus E protein (r Egp). Extracted from cell culture supernatant infected with type 2 dengue virus