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目的 研究氯沙坦与吲达帕胺合用对老年 2型糖尿病伴高血压的降压疗效及对代谢的影响。方法 53例老年 2型糖尿病伴轻 中度原发性高血压病人 ,随机分为两组 :氯沙坦组 2 7例 ,单用氯沙坦 50mg ,每日 1次 ;氯沙坦合用吲达帕胺组 2 6例 ,氯沙坦 50mg ,每日 1次 ,加吲达帕胺 2 5mg ,每日 1次。两组疗程均 1 2周 ,观察两组治疗前后的随测血压、血糖、血脂、血尿酸、血钾和肝肾功能。结果 氯沙坦合用吲达帕胺组降压总有效率明显优于氯沙坦组。结论 氯沙坦合用吲达帕胺对老年 2型糖尿病伴高血压更为有效、安全。
Objective To study the antihypertensive effects of losartan and indapamide combined with hypertension on senile type 2 diabetes mellitus and its effect on metabolism. Methods Fifty-three elderly patients with type 2 diabetes mellitus and mild to moderate essential hypertension were randomly divided into two groups: losartan group 27 cases, losartan 50 mg alone, once daily; losartan combined with indacarb 26 cases of the group of patients with amiodarone, losartan 50mg, 1 day, add 25 mg of indapamide, 1 day. Two groups of treatment were 12 weeks, before and after treatment with the observed blood pressure, blood glucose, blood lipids, serum uric acid, potassium and liver and kidney function. Results Total effective rate of losartan plus indapamide was significantly better than losartan. Conclusion Losartan combined with indapamide is more effective and safe for elderly type 2 diabetes with hypertension.