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目的探讨不同治疗方案介导血清C反应蛋白(CRP)、镁离子(Mg2+)及脂联素水平治疗妊娠期糖尿病对母婴结局的影响差异。方法收集2012年1月-2014年5月来我院就诊的妊娠期糖尿病孕妇224例,随机分为试验组和对照组各112例。2组患者均采取适宜的饮食控制和运动疗法,试验组于妊娠30周内行胰岛素皮下注射血糖控制治疗,对照组于妊娠30周后行胰岛素皮下注射血糖控制治疗。2组患者持续血糖控制治疗直至分娩,分别检测2组患者治疗后血清CRP、Mg2+及脂联素水平,观察2组母婴结局。结果治疗后2组患者血清CRP水平较治疗前下降,而Mg2+和脂联素水平升高,且试验组变化幅度大于对照组;试验组孕妇和新生儿并发症发生率均低于对照组,差异均有统计学意义(P<0.05)。结论早期胰岛素皮下注射治疗妊娠期糖尿病可显著降低CRP、升高Mg2+和脂联素水平,并改善母婴结局。
Objective To investigate the effects of different treatment regimens on serum maternal-to-infant outcomes in gestational diabetes mellitus (DM) with serum C-reactive protein (CRP), magnesium (Mg 2+) and adiponectin levels. Methods Totally 224 pregnant women with gestational diabetes mellitus who visited our hospital from January 2012 to May 2014 were randomly divided into two groups: experimental group and control group, with 112 cases each. The patients in both groups were given appropriate diet control and exercise therapy. The experimental group received insulin subcutaneous injection of glycemic control within 30 weeks of gestation while the control group received insulin subcutaneous injection of glycemic control 30 weeks after gestation. The patients in two groups continued to control their blood sugar until delivery. The levels of serum CRP, Mg2 + and adiponectin in two groups were detected after treatment, and the maternal and infant outcomes were observed. Results After treatment, serum CRP level decreased in both groups and levels of Mg2 + and adiponectin in the two groups were significantly higher than those in the control group. The incidence of complications of pregnant women and newborns in the experimental group was lower than that of the control group All were statistically significant (P <0.05). Conclusion Early subcutaneous injection of insulin in gestational diabetes mellitus can significantly reduce CRP, increase the levels of Mg2 + and adiponectin, and improve maternal and infant outcomes.