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目的 :观察脂调康胶囊对高脂血症大鼠血清apoA Ⅰ、apoB10 0的影响。 方法 :喂食高脂饲料方法复制大鼠高脂血症模型 ,以脂必妥为对照 ,检测各组大鼠血清apoA Ⅰ、apoB10 0的含量。 结果 :脂调康胶囊可显著升高模型大鼠血清apoA Ⅰ含量 ,降低apoB10 0含量。 结论 :脂调康胶囊通过提高apoA Ⅰ含量 ,增强LCAT和LPL的活性表达而调节血脂 ,这可能是脂调康胶囊治疗高脂血症的主要机制。
Objective : To observe the effect of Zhitukang Capsule on serum apoA I and apoB10 0 in rats with hyperlipidemia. METHODS: Hyperlipidemia model rats were fed with high-fat diet, and the levels of serum apoA I and apoB10 0 were measured in each group. Results : Zhitukang Capsule can significantly increase serum apoA I content in model rats and reduce apoB10 0 content. Conclusion : Zhitukang Capsule can regulate blood lipids by increasing the content of apoA I and increasing the expression of LCAT and LPL. This may be the main mechanism of Zhitukang Capsule in the treatment of hyperlipidemia.