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Effects of four herbicides (paraquat,acetochlor,nicosulfumn and atrazine) on the growth of maize and control effect of plant quantity and fresh weight of weeds were studied.The results showed that 15 days after spraying the herbicides on weeds,the prevention and control effect of paraquat on weeds was the optimum,and its effects on the plant quantity and fresh weight of weeds were above 81.57％;the prevention and control effect of acetochlor on weeds was the second best;the prevention and control effect of atrazine on weeds was the worst,and its effects on the plant quantity and fresh weight of weeds were only 51.04％ and 37.86％.After 30 or 45 days,the prevention and control effect of atrazine and nicosulfuron on weeds in the maize fields was better than the other herbicides,and their effects on the plant quantity and fresh weight of weeds were higher than 70.00％ and 85.00％.Acetochlor and paraquat had certain phytotoxicity to the growth of maize after about 15 days,and its leaves became yellow and grew slowly.On the whole,nicosulfuron had good prevention and control effect on weeds and had no phytotoxicity to the growth of maize.